Interest in participating in clinical research: A study of essential tremor patients
Identifieur interne : 002D96 ( Main/Exploration ); précédent : 002D95; suivant : 002D97Interest in participating in clinical research: A study of essential tremor patients
Auteurs : Elan D. Louis [États-Unis] ; Lakeisha M. Applegate [États-Unis] ; Eileen Rios [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-01.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Biomedical Research, Clinical trial, Demography, Epidemiology, Essential Tremor (diagnosis), Essential Tremor (psychology), Female, Human, Humans, Male, Nervous system diseases, Neurologic Examination, Patient Participation, Questionnaires, Severity of Illness Index, Tremor, clinical trials, epidemiology, essential tremor, research.
- MESH :
- diagnosis : Essential Tremor.
- psychology : Essential Tremor.
- Biomedical Research, Demography, Female, Humans, Male, Neurologic Examination, Patient Participation, Questionnaires, Severity of Illness Index.
Abstract
Enrolling essential tremor (ET) patients in clinical research can be challenging. Investigators can maximize recruitment by targeting patient subgroups with greater interest in participation. Nothing has been published on factors that are associated with higher levels of interest in participation. The objective of this study was to identify factors associated with higher levels of interest in participating in clinical research on ET. A total of 149 ET patients were questioned about level of interest in participating in future research. Two questions were used, although one was of primary interest. Interest was rated from 0 to 10 (maximal). Data were collected on demographic factors, family history, and tremor‐related disability. Tremor severity was assessed. The mean level of interest was 8.0 ± 2.3. Level of interest was not related to age of tremor onset, tremor duration, tremor severity, extent of tremor‐related disability, or use of tremor medication. Level of interest was related to family history of tremor (P < 0.05), concern that other family members might develop tremor (P < 0.05), >2 versus 0 live births in women (P < 0.05), the view that the tremor worsens with age (P < 0.05), and presence of head tremor (P = 0.05). A variety of factors were identified that were associated with greater interest in participating in clinical research. These observations should be assessed in additional patient samples. Investigators may use our observations to identify and target patients for clinical trials and other research. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21179
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-01">2007-01</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="133">133</biblScope><biblScope unit="page" to="138">138</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">E787580A6F46300EA75521D127235A9EDEBB897A</idno><idno type="DOI">10.1002/mds.21179</idno><idno type="ArticleID">MDS21179</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biomedical Research</term><term>Clinical trial</term><term>Demography</term><term>Epidemiology</term><term>Essential Tremor (diagnosis)</term><term>Essential Tremor (psychology)</term><term>Female</term><term>Human</term><term>Humans</term><term>Male</term><term>Nervous system diseases</term><term>Neurologic Examination</term><term>Patient Participation</term><term>Questionnaires</term><term>Severity of Illness Index</term><term>Tremor</term><term>clinical trials</term><term>epidemiology</term><term>essential tremor</term><term>research</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Essential Tremor</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Essential Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biomedical Research</term><term>Demography</term><term>Female</term><term>Humans</term><term>Male</term><term>Neurologic Examination</term><term>Patient Participation</term><term>Questionnaires</term><term>Severity of Illness Index</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Epidémiologie</term><term>Essai clinique</term><term>Homme</term><term>Système nerveux pathologie</term><term>Tremblement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="fr">Enrolling essential tremor (ET) patients in clinical research can be challenging. Investigators can maximize recruitment by targeting patient subgroups with greater interest in participation. Nothing has been published on factors that are associated with higher levels of interest in participation. The objective of this study was to identify factors associated with higher levels of interest in participating in clinical research on ET. A total of 149 ET patients were questioned about level of interest in participating in future research. Two questions were used, although one was of primary interest. Interest was rated from 0 to 10 (maximal). Data were collected on demographic factors, family history, and tremor‐related disability. Tremor severity was assessed. The mean level of interest was 8.0 ± 2.3. Level of interest was not related to age of tremor onset, tremor duration, tremor severity, extent of tremor‐related disability, or use of tremor medication. Level of interest was related to family history of tremor (P < 0.05), concern that other family members might develop tremor (P < 0.05), >2 versus 0 live births in women (P < 0.05), the view that the tremor worsens with age (P < 0.05), and presence of head tremor (P = 0.05). A variety of factors were identified that were associated with greater interest in participating in clinical research. These observations should be assessed in additional patient samples. Investigators may use our observations to identify and target patients for clinical trials and other research. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region><settlement><li>New York</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name></region><name sortKey="Applegate, Lakeisha M" sort="Applegate, Lakeisha M" uniqKey="Applegate L" first="Lakeisha M." last="Applegate">Lakeisha M. Applegate</name><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><name sortKey="Rios, Eileen" sort="Rios, Eileen" uniqKey="Rios E" first="Eileen" last="Rios">Eileen Rios</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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